Brain Wiring in Autism: In recent years it has been discovered that abnormal connections between brain regions in autism may be the fundamental abnormality that causes the symptoms of autism. In collaboration with Janet Lainhart’s laboratory, we are testing theories about which connections are abnormal, how these connection deficiencies can be used for diagnosis and prognosis in autism, how these abnormalities cause dynamical changes in brain networks to cause autistic traits, and what interventions may be possible to help improve the lives of children and adults with autism.

Transcendent Experience and Focused Attention: In collaboration with Michael Johnson, our laboratory has commenced a study of Zen masters, hoping to learn what changes in the brain come from decades of focused attention and compassion training, and where the brain goes during periods of intense contemplation.

Effects of Adolescent Marijuana Use on the Brain: In collaboration with Deborah Yurgelun-Todd’s laboratory, we are studying the effects of acute and chronic cannabinoid exposure to brain function, what predispositions may contribute to adolescent drug use, and what risks may occur from prolonged exposure during development.

The Simulated Brain Project: We seek to understand the core networks underlying cognitive function, control of attention, and introspection in the brain. Our goal is to use this information to develop models of the brain in silico, with computer modeling of brain networks to help us learn how the brain performs its core functions.

Functional Targeting for Deep Brain Stimulation: A revolution is taking place in neurosurgery, with minimally invasive techniques of cortical stimulation and deep brain stimulation allowing new therapies for movement disorders, psychiatric illness, and epilepsy. We are developing image guidance techniques for functional neurosurgery of essential tremor, Parkinson’s Disease, and blindness, hoping to help cure movement disorders and restore sight.